期刊
MATERIALS RESEARCH INNOVATIONS
卷 17, 期 7, 页码 507-514出版社
MANEY PUBLISHING
DOI: 10.1179/1433075X13Y.0000000100
关键词
Au; Silica; Core shell; Nanoparticle; Poly(ethylene glycol); X-ray contrast agent
This work describes X-ray imaging of mouse using colloid solution of silica coated Au (Au/SiO2) nanoparticles surface modified with poly(ethylene glycol) (PEG) (Au/SiO2/PEG). A colloid solution of Au nanoparticles was prepared by reducing Au ions (III) with sodium citrate. Au/SiO2 nanoparticles were fabricated by a sol-gel method using tetraethylorthosilicate, water and sodium hydroxide in ethanol in the presence of Au nanoparticles surface modified with (3-aminopropyl)trimethoxysilane. A computed tomography value of the Au/SiO2 colloid solution with an Au concentration of 0.083M was as high as 1421.2 Hounsfield units, which was higher than that of a commercial X-ray contrast agent with the same iodine concentration. Surface modification of the Au/SiO2 particles with PEG, or PEGylation of the particle surface, was performed using (3-aminopropyl) trimethoxysilane and PEG for the Au/SiO2 particles. Tissues of mouse could be imaged by injecting the colloid solutions of Au/SiO2 particles or Au/SiO2/PEG particles into it. The PEGylation provided an increase in residence time of particles in the mouse.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据