期刊
MATERIALS RESEARCH BULLETIN
卷 57, 期 -, 页码 97-102出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.materresbull.2014.05.023
关键词
Inorganic compounds; Nanostructures; Chemical synthesis; Magnetic properties
资金
- National Natural Science Foundation of China [21271130, 21371122]
- program for Changjiang Schlolars and Innovative Research Team in University [IRT1269]
- Shanghai Science and Technology Fund Project [12ZR1421800, 13520502800]
- Pujiang Program of Shanghai Education Commission in China [13111406600]
- Shanghai Municipal Education Commission [13ZZ110]
- Shanghai Normal University [DXL122, SK201339]
The monodisperse silica-coated manganese oxide nanoparticles (Mn3O4@SiO2 NPs) were synthesized via the high temperature pyrolysis approach and were aminated through silanization. The amine-functionalized Mn3O4 NPs enabled the covalent conjugation of hydrophilic methoxypoly(ethylene glycol) (PEG) and the targeting ligand of folate (FA) onto their surface. The formed PEG and FA modified Mn3O4 NPs (Mn3O4@SiO2(PEG)-FA) exhibited the good colloidal stability in the simulated biological medium and the targeting ability to HeLa cells overexpressed the FA receptor. The T-1-weighted magnetic resonance (MR) imaging and inductively coupled plasma atomic emission spectroscopy (ICP-AES) analysis of Mn3O4@SiO2(PEG)-FA NPs further demonstrated their targeting ability in tumor. (C) 2014 Elsevier Ltd. All rights reserved.
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