A novel simple in situ biomimetic and simultaneous deposition of bonelike apatite within biopolymer matrix as bone graft substitutes

A novel simple in situ biomimetic strategy used for the first time for rapid induction of bonelike apatite nanosized into the chitosan (as) matrix. The precipitated particles from the surrounding simulated body fluid within polymer matrix during the hydrothermal process showed a uniform distribution and perfect matching with bonelike minerals. The excellent bone-bonding property and biocompatibility of bonelike apatite could provide a suitable environment for the attachment and ingrowth of MC3T3-E1 osteoblasts. The bioactive apatite film designed in this article can make the novel bonelike apatite/ CIS matrix nanocomposite as attractive substitutes for bone graft and regeneration. (C) 2014 Elsevier B.V. All rights reserved.