期刊
MATERIALS LETTERS
卷 95, 期 -, 页码 182-185出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2012.12.084
关键词
Biomaterials; Cyborg cells; Magnetic materials; Magnetophoresis; Microfluidic; Polyelectrolytes
资金
- Engineering and Physical Sciences Research Council (EPSRC), UK
- Government of Tatarstan
- EPSRC [EP/E065414/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E065414/1] Funding Source: researchfish
We demonstrate a rapid method of coating a layer of polymer onto magnetically modified yeast cells, so-called cyborg cells, in continuous flow within a microfluidic chamber. Laminar flow streams of polyelectrolyte and washing buffers were generated across the chamber, and the magnetic cells were deflected sequentially through the co-flowing streams via an external magnet, allowing polyelectrolyte deposition onto the cells immediately followed by the washing step, all in less than 90 s. This simple deposition technique shows promise for the functionalization of such cyborg cells for applications including bioelectronics, bioanalysis, and toxicity screening, while the addition of more reagent streams would enable the fabrication of multilayered capsules. (C) 2013 Elsevier B.V. All rights reserved.
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