期刊
MATERIALS LETTERS
卷 107, 期 -, 页码 280-283出版社
ELSEVIER
DOI: 10.1016/j.matlet.2013.05.070
关键词
Collagen porous scaffold; Gradient pore structure; Pore size; Porogen; Ice particulate; Tissue engineering; Cartilage regeneration
资金
- World Premier International Research Center Initiative (WPI) from the Ministry of Education, Culture, Sports, Science and Technology of Japan
Direct comparison using scaffolds with a gradient pore size structure is important to investigate the effect of pore size on tissue regeneration. Collagen porous scaffolds with a pore size gradient were prepared by using pre-prepared ice particulates as a porogen material. The ice particulates had diameters of 150-250, 250-355, 355-425 and 425-500 mu m. The gradient collagen scaffolds had well-interconnected pore structures with compactly packed spherical pores. The gradient pore scaffolds were used for culture of bovine articular chondrocytes, directly examining the effect of pore size on cartilage regeneration. Chondrocytes adhered and showed a homogenous distribution throughout the scaffolds. In vivo implantation results indicated that the micropores in the scaffolds prepared with ice particulates in the range of 150-250 mu m showed the best effect on cartilage regeneration. (C) 2013 Elsevier Ltd. All rights reserved.
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