期刊
MATERIALS LETTERS
卷 81, 期 -, 页码 16-19出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2012.04.142
关键词
Disinfectant; Root canal treatment; Nanosphere; Controlled release; Mineralization
资金
- One Hundred Talent Project, SIC-CAS
- ARC [DP120103697]
The aim of this study is to develop a new intra-canal disinfectant-carrier for infected canal treatment. To achieve this purpose, a new porous Ca-Si (CS)-based nanosphere was synthesized and characterized. Results showed that the nanospheres can infiltrate into dentinal tubules and released the ampicillin over one week time in a sustained manner. The release of ampicillin from spheres has significant antibacterial property. Extensive and well-organized in vitro mineralization and crystallization of apatite were induced on the surface of dentin slices covered by CS nanospheres. All these features indicate that the porous CS nanospheres may be developed into a new intra-canal disinfectant-carrier for infected canal treatment. (C) 2012 Elsevier B.V. All rights reserved.
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