期刊
MATERIALS LETTERS
卷 77, 期 -, 页码 74-77出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2012.02.102
关键词
Biomaterials; Porous materials; Polymer; Hydrogels; pH-sensitive; Degradable
资金
- National Natural Science Foundation of China [51003103, 50973108]
- Ministry of Science and Technology of China [2010DFB50890]
- Scientific Development Program of Jilin Province [201101082, 20090135]
A series of poly(acrylic acid) hydrogels crosslinked by poly(L-glutamic acid)-g-(2-hydroxyl methacrylamide) (PGA-g-HEMA) were synthesized. The hydrogels showed pH-dependent swelling-deswelling behaviors. The hydrogels exhibited lower swelling ratios in an acidic medium because of the protonation of both acrylic acid (AA) and glutamic acid (GA) acid group residues. In contrast, in a basic medium (pH 8.3), the highest swelling ratios (SR) reached 5 to 10 times higher than those in the acidic medium. The SR increased sharply when the pH increased above 4, which is close to the pK(a) of PAA and PGA, resulted from the ionization of the AA and GA residues. The swelling ratios of the hydrogels with different crosslinking density in neutral medium (pH = 7) were 33.70, 30.75, 29.42, 28.11, respectively. When a model protein, BSA, was loaded within the pH-sensitive hydrogels. BSA nature was retained and protected by the hydrogels at acidic pH, and released at neutral pH. Therefore, the hydrogels may have potential applications in oral drug delivery systems. (C) 2012 Elsevier B.V. All rights reserved.
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