期刊
RESEARCH ON CHEMICAL INTERMEDIATES
卷 41, 期 12, 页码 9863-9869出版社
SPRINGER
DOI: 10.1007/s11164-015-1993-6
关键词
Citric acid; Green catalyst; Highly substituted piperidines; beta-Ketoesters
Citric acid has been used as a green and efficient catalyst for one-pot, multi-component synthesis of highly substituted piperidines by condensation of aromatic aldehydes, aromatic amines, and beta-ketoesters in MeOH at ambient temperature. This method has several advantages including use of a nonhazardous and inexpensive catalyst, easy work-up, clean reaction conditions, and high yields.
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