期刊
MATERIALS CHEMISTRY AND PHYSICS
卷 129, 期 1-2, 页码 446-450出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2011.04.040
关键词
Polymer; Biomaterial; Antimicrobial; Methylene blue; Toluidene blue; Nanogold
Polyurethane polymer sheets were embedded with methylene blue (MB), toluidine blue (TBO) and 2 nm gold nanoparticles by a swell-shrink encapsulation process using an acetone water mixture. The polymers were characterised by IR, UV-vis, SEM/WDX and mechanical testing. The dye impregnated polymers were potent at killing suspensions of Staphylococcus aureus under white illumination with a hospital light source (2000 lux) showing a 2.8 log(10) kill (MB) and a 4.3 log(10) kill (TBO) compared to controls when exposed to 24 h of illumination. Notably the incorporation of gold nanoparticles with the dyes enhanced the observed kill to 3.8 log(10) (MB) and 4.8 log(10) (TBO). This is the first time that a derivatised polyurethane polymer used in catheters has been shown to be effective in killing bacteria using white light illumination. (C) 2011 Elsevier B.V. All rights reserved.
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