期刊
MATERIALS CHEMISTRY AND PHYSICS
卷 131, 期 1-2, 页码 485-494出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2011.10.008
关键词
Hydroxyapatite; CoFe2O4; Nanoparticles; Hyperthermia; Magnetic drug target (MDT)
资金
- Department of Physics, Faculty of Science, Kasetsart University
- Thailand Center of Excellence in Physics (ThEP)
This research focuses on the synthesis of composite CoFe2O4 (CoF) nanoparticles coated with SiO2 using hydroxyapatite (HAP) as a template (CoFSi) and the pH controlled release of indomethacin (IMC) drug from this nanocomposite. The formation of the CoFe2O4-HAp (CoFHAp) nanoparticles and of the CoFe2O4@SiO2 (CoFSi) nanoparticles were monitored using XRD, FT-IR, that TEM, SEM, and ED studies. The magnetic properties are measured with a VSM. The TEM images showed the CoFe2O4 to have a core-shell structure encapsulated by a silica coating with an average size of 50 nm. BET showed the mean pore sizes of the silica shell to be approximately 10-20 nm and the surface area to be 212.8 m(2) g(-1). Magnetization (M-s) and remnant (M-r) magnetic properties of CoFSi nanocomposite decreased upon silica coating (from similar to 14 to 2 emu g(-1) for Ms of CoF and CoFSi, respectively). In contrast, the coercivity (H-c) of the uncoated CoFe2O4 (317 Oe) is lower than that of the coated nanocomposites (1250 Oe of CoFSi). In vitro drug loading of the CoFSi nanoparticles and its pH-responsive (pH = 4.0 and 7.0) controlled release were investigated using IMC as a model drug. It was seen that the release of the IMC drug was significantly faster at a pH of 4.0 compared to that at a neutral pH 7.0. Furthermore, the lower concentration of ions release (iron and cobalt) from CoFSi was observed after aging for 50 h. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据