期刊
MATERIALS CHEMISTRY AND PHYSICS
卷 128, 期 1-2, 页码 83-89出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2011.02.039
关键词
Biomaterials; Nanostructures; Electron microscopy; Fourier transform infrared spectroscopy (FTIR)
资金
- University Grants Commission, New Delhi
Extracellular synthesis of copper nanoparticles was carried out using stem latex of a medicinally important plant. Euphorbia nivulia. The nanoparticles were stabilized and subsequently capped by peptides and terpenoids present within the latex. The protein capping is a promising biocompatible vehicle for destruction of tumor/cancer cells. The cytotoxicity potential of the plant protein capped nanoparticles was evaluated using various parameters like MTT cell viability assay and extracellular lactate dehydrogenase (LDH) release in cancer cell line. Other parameters that determine the oxidative stress viz., reactive oxygen species (ROS) generation, intracellular reduced glutathione (GSH), malondialdehyde (MDA), superoxide generation and acridine orange/ethidium bromide staining were also investigated. The present study led to the conclusion that copper nanoparticles are toxic to A549 cells in a dose dependent manner. The nontoxic aqueous formulation of latex capped copper nanoparticles can be directly used for administration/in vivo delivery of nanoparticles for cancer therapy. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据