期刊
REPRODUCTIVE TOXICOLOGY
卷 54, 期 -, 页码 58-65出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2014.09.012
关键词
Fetal mammary gland; Mammary gland development; Xenoestrogens; Endocrine disruptors; Environmental exposure; Prenatal exposure
资金
- Avon Foundation [02-2009-093, 02-2011-025]
- National Institute of Environmental Health Sciences [R01ES08314, RC2ES018822]
Iatrogenic gestational exposure to diethylstilbestrol (DES) induced alterations of the genital tract and predisposed individuals to develop clear cell carcinoma of the vagina as well as breast cancer later in life. Gestational exposure of rodents to a related compound, the xenoestrogen bisphenol-A (BPA) increases the propensity to develop mammary cancer during adulthood, long after cessation of exposure. Exposure to BPA during gestation induces morphological alterations in both the stroma and the epithelium of the fetal mammary gland at 18 days of age. We postulate that the primary target of BPA is the fetal stroma, the only mammary tissue expressing estrogen receptors during fetal life. BPA would then alter the reciprocal stroma-epithelial interactions that mediate mammogenesis. In addition to this direct effect on the mammary gland, BPA is postulated to affect the hypothalamus and thus in turn affect the regulation of mammotropic hormones at puberty and beyond. (C) 2014 Elsevier Inc. All rights reserved.
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