期刊
REPRODUCTIVE TOXICOLOGY
卷 57, 期 -, 页码 111-120出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2015.05.018
关键词
Preterm birth; Women; Organochlorine pesticides; Cytokines; Prostaglandins; Gene-environment interactions
资金
- Indian Council of Medical Research [5/7/516/11-RHN]
- Council of Scientific and Industrial Research (CSIR)
Elevated inflammation is a known risk factor in the pathogenesis of PTB. Despite intensive research, the etiology of idiopathic PTB is still unknown. The present study was designed to explore associations of blood concentrations of organochlorine pesticides (OCPs) with inflammatory/antioxidant gene expression, and cytokines and prostaglandin levels in PTB cases. Significantly high levels of alpha, beta-hexachlorocyclohexane (alpha, beta-HCH), dichlorodiphenyldichloroethane (o'p'-DDD), dichlorodiphenyldichloroethylene (p'p'-DDE), increased expression of cyclooxygenase-2 (COX-2), and decreased expression of manganese superoxide dismutase (Mn-SOD) and catalase (CAT) genes were seen in PTB cases. Also, increased protein levels of interleukin-6 (IL-6) and decreased protein levels of interleukin-4 (IL-4) and prostaglandin F2 alpha (PGF2 alpha) were found in maternal blood of PTB cases as compared to term controls. Elevated levels of beta-HCH along with high expression of COX-2 gene or low expression of Mn-SOD or CAT genes were associated with the decrease in the period of gestation (POG). (C) 2015 Elsevier Inc. All rights reserved.
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