A REVIEW OF CLINICAL DIAGNOSTIC APPLICATIONS OF LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

Liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) technology is emerging as a complementary method to traditional methodology used for clinical applications. Enhanced specificity and high-throughput capabilities are providing significant benefits to clinical diagnostic laboratories conducting routine analyses. This technology is expected to expand rapidly as scientists focus on more complicated challenges that can be solved efficiently by adding LC/MS/MS to their arsenal of techniques. (C) 2010 Wiley Periodicals, Inc., Mass Spec Rev 29:930-944, 2010