期刊
MARINE POLLUTION BULLETIN
卷 135, 期 -, 页码 514-520出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.marpolbul.2018.07.051
关键词
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资金
- New Jersey Water Resources Research Institute [USGS-G16AP00071(07043)]
- Chateaubriand Fellowship of the Office for Science & Technology of the Embassy of France in the United States
Antibiotic resistance is a global public health issue and metal exposure can co-select for antibiotic resistance. We examined genome sequences of three multi-drug and metal resistant bacteria: one Shewanella sp., and two Vitnio spp., isolated from the gut of the mummichog fish (Fundulus heteroclitus). Our primary goal was to understand the mechanisms of co-selection. Phenotypically, the strains showed elevated resistance to arsenate, mercury, and various types of beta-lactams. The genomes contained genes of public health concern including one carbapenemase (bla(OXA-48)). Our analyses indicate that the co-selection phenotype is mediated by chromosomal resistance genes and cross-resistance. No evidence of co-resistance was found; most resistance genes were chromosomally located. Moreover, the identification of many efflux pump gene homologs indicates that cross-resistance and/or co-regulation may further contribute to resistance. We suggest that the mummichog gut microbiota may be a source of clinically relevant antibiotic resistance genes.
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