期刊
MARINE POLLUTION BULLETIN
卷 76, 期 1-2, 页码 77-84出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.marpolbul.2013.09.027
关键词
Integrons; Integrase; Antibiotic resistance; Urbanization; Wastewater treatment
资金
- South Carolina Sea Grant Consortium
- Slocum-Lunz Grant [21600-KA43]
- Arnold Fellowship (USC, School of Public Health)
- Arnold School of Public Health Seed grant
The impact of human activity on the spread of antibiotic resistant bacteria throughout coastal estuarine ecosystems is not well characterized. It has been suggested that laterally transferred genetic agents, such as integrons, play a role in the spread of resistant bacteria throughout ecosystems. This study compares the distribution of three integron classes throughout a coastal estuarine ecosystem. To determine integron distribution patterns, DNA was extracted from sediment and water collected at seven sites throughout two estuaries with different levels of anthropogenic input and integrons analyzed using quantitative PCR. The data show that while all three integron classes are present, the relative abundance is different, with class 2 integrons significantly elevated in areas of high anthropogenic input and class I integrons elevated in areas of low input. Our results provide a foundation for using integron gene distribution as a biomarker of urban impact on antibiotic resistance gene flow and ecosystem health. (C) 2013 Elsevier Ltd. All rights reserved.
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