期刊
MARINE POLLUTION BULLETIN
卷 64, 期 7, 页码 1445-1451出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.marpolbul.2012.04.007
关键词
Oil spill; Marine medaka; Model fish; Developmental toxicity; Early life stage; Risk assessment
资金
- National Natural Science Foundation of China [41106089]
- National High Technology Research and Development Program of China [2007AA09Z126]
- Scientific Research Special Fund of Marine Public Welfare Industry [200805090, 201105013, 201205012]
- Key Laboratory Fund of Marine Spill Oil Identification and Damage Assessment Technology, State Oceanic Administration [2010-02]
- changjiang distinguish research project [IRT0941]
The mode of action of PAHs that causes fish developmental malformations is unclear. The embryotoxicity of marine medaka (Oryzias melastigma) was investigated after individual exposure to three- to five-ring PAHs Phe, Py, and BaP or co-exposure with alpha-ANF for 18 days. We found that the relationships between EROD induction and developmental deformities of embryos showed a various pattern under different exposure scenarios of Phe, Py, and BaP, which suggested possibly different modes of action in determining the developmental toxicities. As for co-exposure scenarios of each PAH combined with ANF, it showed potentially synergistic effects. The inhibited CYP1A mediated enzyme activity by ANF after co-exposure did not effectively alleviate developmental toxicity of embryo. It showed potentially synergistic effects after co-exposure of marine fish embryos to CYP1A inhibitors and PAH-type CYP1A inducers. Heart deformities in the early life stages of marine medaka were recommended as a biomarker for indicating the extent of PAH pollution. (C) 2012 Elsevier Ltd. All rights reserved.
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