期刊
MARINE POLLUTION BULLETIN
卷 63, 期 5-12, 页码 267-276出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.marpolbul.2011.05.014
关键词
Marine medaka; Hepcidin; Innate immune response; Immunotoxicology; Bacterial challenge
资金
- University Grants Committee of the Hong Kong Special Administration Region, China [AoE/P-04/2004]
- State Key Laboratory in Marine Pollution (CityU)
- Hong Kong-France Research Collaboration Grant [9231003]
- Minjiang Scholar Program
The objective of this study is to develop the marine medaka Oryzias melastigma as a potential marine fish model for innate immune and immunotoxicological studies. Hepcidin plays an important role in innate immune system. Two hepcidin genes (OM-hep1 and OM-hep2) were identified and characterized in the O. melastigma, which were highly conserved with other reported hepcidins. During embryogenesis, significant elevation of OM-hep1 and OM-hep2 transcripts were coincided with liver development in the embryos. In adult medaka, differential tissue expressions of both hepcidin transcripts were evident: high in liver, moderate in spleen and low in non-immune tissues. After bacterial challenge, the two hepcidin mRNAs were rapidly and remarkably induced in liver and spleen, suggesting the two OM-hepcidins in O. melastigma play a complementary role in innate defense. Gender difference in time of induction and extent of the two hepcidin mRNAs elevation in infected O. melastigma should be considered in immunotoxicological studies. (C) 2011 Elsevier Ltd. All rights reserved.
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