期刊
MARINE POLLUTION BULLETIN
卷 63, 期 5-12, 页码 412-416出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.marpolbul.2011.05.007
关键词
Endocrine disruption; Estrogen-active compounds; Teleost fish; Estrogen receptors; Immune genes; Pathogen susceptibility
资金
- Swiss National Science Foundation [111028, 118165, 130640]
Endocrine disruption, in particular disruption by estrogen-active compounds, has been identified as an important ecotoxicological hazard in the aquatic environment. Research on the impact of endocrine disrupting compounds (EDCs) on wildlife has focused on disturbances of the reproductive system. However, there is increasing evidence that EDCs affect a variety of physiological systems other than the reproductive system. Here, we discuss if EDCs may be able to affect the immune system of fish, as this would have direct implications for individual fitness and population growth. Evidence suggesting an immunomodulatory role of estrogens in fish comes from the following findings: (a) estrogen receptors are expressed in piscine immune organs, (b) immune gene expression is modulated by estrogen exposure, and (c) pathogen susceptibility of fish increases under estrogen exposure. (C) 2011 Elsevier Ltd. All rights reserved.
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