期刊
MARINE ENVIRONMENTAL RESEARCH
卷 141, 期 -, 页码 233-246出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.marenvres.2018.09.009
关键词
Marine fish; Detoxification metabolism; Oxidative stress; Genotoxicity; Neurological impairment; Energetic balance
资金
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BD/84061/2012, SFRH/BPD/109951/2015]
- Investigator FCT program [IF/01744/2013]
- FCT - Foundation for Science and Technology [UID/Multi/04423/2013]
- European Regional Development Fund (ERDF)
- CESAM [UID/AMB/50017 - POCI-01-0145-FEDER-007638]
- FCT/MCTES through national funds (PIDDAC)
- FEDER, within the PT2020 Partnership Agreement and Compete 2020
Oxytetracycline (OTC) is an antibiotic widely used in human and veterinary medicines. Since the primary toxicity occurs mainly at molecular/biochemical levels, the study of different biological responses corresponds to a sensitive and crucial approach. The aim of the present study was to assess the toxic effects of OTC in gilthead seabream (Spares aurata) through the use of multibiomarkers and elucidate about the possible toxicological mechanisms involved. S. aurata were acutely (96 h: 0.04-400 mu g/L) and chronically (28 days: 0.0004-4 mu g/L) exposed to OTC. Detoxification, antioxidant defense, lipid peroxidation, genotoxicity, neurotransmission and energy metabolism biomarkers were evaluated. OTC impaired the detoxification pathways and caused peroxidative damage and genotoxicity. The relevance of the here-obtained data is high, since significant effects were recorded for levels already reported to occur in the wild, meaning that environmentally-exposed marine organisms (including those cultured at fish farms) are not completely exempt of risks posed by OTC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据