期刊
MARINE ENVIRONMENTAL RESEARCH
卷 94, 期 -, 页码 7-15出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.marenvres.2013.11.001
关键词
CYP3A-like; mRNA; Benzo[a]pyrene; Pollution effects; Ecotoxicology; Chlamys farreri; CYPs expression
资金
- National Natural Science Foundation of China [30972237]
In this study, we isolated a CYP3A-like gene from ovary of the scallop (Chlamys farreri). High levels of CYP3A-like gene expression occur in the digestive gland and gonad, which suggested their role in the metabolism of steroids and xenobiotics. Scallops were exposed to a polycyclic aromatic hydrocarbons (PAHs), benzo[a]pyrene (B[a]P) for 10 days. The CYP4 and CYP3A-like gene can be up-regulated by Nap in a dose-dependent manner after 10 days exposure. But no induction of the CYP3A-like was observed in 10 mu g/L B[a]P group. The CYP1A-like expression can only be induced by 0.025 mu g/L B[a]P. 0.5 and 10 mu g/L B [a]) caused significant DNA damage and 10 mu g/L B[a]l) can also lead to oxidative damage. These results demonstrate that the mollusk CYPs can be modulated by environmental pollutant, and the blocked induction of CYP3A-like and CYP1A-like expression probably results from the high genotoxicity and oxidative damage partly. (C) 2013 Elsevier Ltd. All rights reserved.
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