期刊
ACTA DERMATO-VENEREOLOGICA
卷 95, 期 2, 页码 191-196出版社
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-1864
关键词
Malassezia spp.; atopic dermatitis; allergen-specific IgE; SCORAD
类别
The significance of allergen-specific IgE as marker for severity of atopic dermatitis is controversial. The aim of this study was to determine the frequency of IgE-mediated sensitisation to food and environmental allergens in 132 children and 67 adults with atopic dermatitis, and its correlation to severity of atopic dermatitis (SCORAD). Total IgE was elevated (>100 KU/l) in 79.7% of adults and 46.8% of children. Sensitisation frequencies to allergens, particularly microbial allergens, were up to 10-fold higher in adults compared to children. Severity of atopic dermatitis correlated with elevated total IgE in adults (r=0.549, p<0.001) and children (r=0.344, p=0.005) and with Malassezia spp.-specific IgE in adults (r=0.429, p=0.007). Total IgE is a marker for severe atopic dermatitis in both age groups. Malassezia spp.-specific IgE is an important allergen-specific marker for severity of atopic dermatitis in adults.
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