期刊
MARINE DRUGS
卷 16, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/md16070242
关键词
zoantharia; Tropical Eastern Pacific; Zoanthus pulchellus; zoanthamine; inflammation
资金
- Secretaria de Educacion Superior, Ciencia, Tecnologia e Innovacion (SENESCYT) [PIC-14-CENAIM-001]
- Marine Institute [PBA/MB/16/01]
- Marine Research Programme by the Irish Government
- NUI Galway
- FEDER [2017 GRC GI-1682 (ED431C 2017/01)]
- Ministerio de Economia, Industria y Competitividad [AGL2014-58210-R, AGL2016-78728-R, ISCIII/PI16/01830, RTC-2016-5507-2, ITC-20161072]
- European Union [POCTEP 0161-Nanoeaters-1-E-1, Interreg AlertoxNet EAPA-317-2016, H2020 778069-EMERTOX]
Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation.
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