期刊
MARINE DRUGS
卷 12, 期 2, 页码 1023-1042出版社
MDPI
DOI: 10.3390/md12021023
关键词
outer membrane; lipopolysaccharide transport; Escherichia coli
资金
- Fondazione Cariplo [2010-0653]
- Regione Lombardia Cooperazione scientifica e tecnologica internazionale [16876 SAL-18]
The bacterial outer membrane (OM) is a peculiar biological structure with a unique composition that contributes significantly to the fitness of Gram-negative bacteria in hostile environments. OM components are all synthesized in the cytosol and must, then, be transported efficiently across three compartments to the cell surface. Lipopolysaccharide (LPS) is a unique glycolipid that paves the outer leaflet of the OM. Transport of this complex molecule poses several problems to the cells due to its amphipatic nature. In this review, the multiprotein machinery devoted to LPS transport to the OM is discussed together with the challenges associated with this process and the solutions that cells have evolved to address the problem of LPS biogenesis.
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