期刊
MARINE DRUGS
卷 12, 期 12, 页码 6236-6253出版社
MDPI
DOI: 10.3390/md12126236
关键词
chitosan; water soluble chitosan; drug carriers; polyelectrolyte complexes; targeted/controlled release
资金
- Anhui University
- National Natural Science Foundation of China
- Doctoral Programs Foundation of Ministry of Education of China
Chitosan, the cationic polysaccharide derived from the natural polysaccharide chitin, has been studied as a biomaterial for more than two decades. As a polycationic polymer with favorable properties, it has been widely used to form polyelectrolyte complexes with polyanions for various applications in drug delivery fields. In recent years, a growing number of studies have been focused on the preparation of polyelectrolyte complexes based on chitosan and its water soluble derivatives. They have been considered well-suited as biomaterials for a number of vital drug carriers with targeted/controlled release profiles, e.g., films, capsules, microcapsules. In this work, an overview highlights not only the favorable properties of chitosan and its water soluble derivatives but also the good performance of the polyelectrolyte complexes produced based on chitosan. Their various types of applications as drug carriers are reviewed in detail.
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