期刊
MARINE DRUGS
卷 12, 期 2, 页码 1102-1115出版社
MDPI
DOI: 10.3390/md12021102
关键词
structural and functional characterization of marine drug; marine biotechnology; bioactive compounds and bioproducts; drug discovery and development
资金
- Rutgers University through an Academic Excellence award
Chemical and biological investigation of the cultured marine soft coral Xenia elongata led to the isolation of two new diterpenes (2, 3). Their structures were elucidated using a combination of NMR and mass spectrometry. Biological evaluations and assessments were determined using the specific apoptosis induction assay based on genetically engineered mammalian cell line D3 deficient in Bak and Bax and derived from a mouse epithelial cell. The diterpenes induce apoptosis in low micromolar concentrations. The results indicate that the previously isolated compound (1) affects cell in a manner similar to that of HSP90 and HDAC inhibitors and in a manner opposite of PI3 kinase/mTOR inhibitors. Compound (3) inhibits selectively HDAC6 in high micromolar concentrations.
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