期刊
MARINE DRUGS
卷 12, 期 5, 页码 2953-2969出版社
MDPI AG
DOI: 10.3390/md12052953
关键词
endophytic fungus; Alternaria sp.; alterporriol; theoretical calculations; ECD; TDDFT; MptpB
资金
- National Natural Science Foundation of China [41276146, 41376149]
- 863 Foundation of China [2011AA09070201]
- Science and Technology Plan Project of Guangdong Province of China [2010B030600004, 2011A080403006]
- Special Financial Fund of Innovative Development of Marine Economic Demonstration Project [GD2012-D01-001]
- China's Marine Commonweal Research Project [201305017]
A new alterporriol-type anthranoid dimer, alterporriol S (1), along with seven known anthraquinone derivatives, (+)-aS-alterporriol C (2), hydroxybostrycin (3), halorosellinia A (4), tetrahydrobostrycin (5), 9 alpha-hydroxydihydrodesoxybostrycin (6), austrocortinin (7) and 6-methylquinizarin (8), were isolated from the culture broth of the mangrove fungus, Alternaria sp. (SK11), from the South China Sea. Their structures and the relative configurations were elucidated using comprehensive spectroscopic methods, including 1D and 2D NMR spectra. The absolute configurations of 1 and the axial configuration of 2 were defined by experimental and theoretical ECD spectroscopy. 1 was identified as the first member of alterporriols consisting of a unique C-10-C-2' linkage. Atropisomer 2 exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC50 value 8.70 mu M.
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