期刊
MARINE DRUGS
卷 12, 期 1, 页码 167-175出版社
MDPI
DOI: 10.3390/md12010167
关键词
marine fungus; Chondrostereum sp.; sesquiterpenoids; chondrosterins; cytotoxic activity
资金
- National Natural Science Foundation of China [30973633, J1103305]
- Guangdong Provincial Science and Technology Research Program [2012A031100005]
- Guangzhou Science and Technology Research Program [2011Y1-00036]
- Fundamental Research Funds for the Central Universities [11lgpy09]
- Special Financial Fund of Innovative Development of Marine Economic Demonstration Project [GD2012-D01-001]
- College Students' Innovative Training Programs of Guangdong Province [1055812311]
Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 mu M.
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