期刊
MARINE DRUGS
卷 12, 期 7, 页码 4096-4109出版社
MDPI
DOI: 10.3390/md12074096
关键词
marine sponge; Hippospongia lachne; sesterterpenoids; absolute configuration; PTP1B
资金
- National Natural Science Fund for Distinguished Young Scholars of China [81225023]
- National Natural Science Fund of China [41106127, 81072573, 81172978, 81302691, 81373321, 81001394, 81202441]
- Shanghai Subject Chief Scientist [12XD1400200]
- Innovation Program of Shanghai Municipal Education Commission [14YZ037]
- National High Technology Research and Development Program of China (863 Projects) [2011AA09070107, 2013AA092902]
Five new sesterterpenoids, compounds 1-5, have been isolated from the sponge Hippospongia lachne off Yongxing Island in the South China Sea. The structures of compounds 1-5 were elucidated through extensive spectroscopic analysis, including HRMS, 1D, and 2D NMR experiments. The stereochemistry, including absolute configurations of these compounds, was determined by spectroscopic, chemical, and computational methods. Compounds 1 and 5 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 5.2 mu M and 8.7 mu M, respectively, more potent than previously reported hippolides.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据