4.7 Article

Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice

期刊

MARINE DRUGS
卷 12, 期 7, 页码 4086-4095

出版社

MDPI
DOI: 10.3390/md12074086

关键词

deferoxamine; enterovirus 71; hand; foot and mouth disease; B cells

资金

  1. National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2012BA139B02]
  2. National Science and Technology Major Projects of Infectious Disease of China [2012ZX10004501]
  3. Youth Foundation of CAMS PUMC [3332013041]

向作者/读者索取更多资源

Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71.

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