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Transcriptomic Messiness in the Venom Duct of Conus miles Contributes to Conotoxin Diversity
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MOLECULAR & CELLULAR PROTEOMICS (2013)
A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity
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MARINE DRUGS (2013)
A Novel Inhibitor of α9α10 Nicotinic Acetylcholine Receptors from Conus vexillum Delineates a New Conotoxin Superfamily
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A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico
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BIOCHEMISTRY (2012)
Distinct Disulfide Isomers of μ-Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels
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Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels
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A Helical Conotoxin from Conus imperialis Has a Novel Cysteine Framework and Defines a New Superfamily
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
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Conus consors Snail Venom Proteomics Proposes Functions, Pathways, and Novel Families Involved in Its Venomic System
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Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach
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JOURNAL OF PROTEOMICS (2012)
Extensive and Continuous Duplication Facilitates Rapid Evolution and Diversification of Gene Families
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Recruitment of Glycosyl Hydrolase Proteins in a Cone Snail Venomous Arsenal: Further Insights into Biomolecular Features of Conus Venoms
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Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome
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MARINE GENOMICS (2012)
Diversity and evolution of conotoxins in Conus virgo, Conus eburneus, Conus imperialis and Conus marmoreus from the South China Sea
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High-resolution picture of a venom gland transcriptome: Case study with the marine snail Conus consors
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Conus Venom Peptide Pharmacology
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BMC GENOMICS (2011)
A novel conotoxin, qc16a, with a unique cysteine framework and folding
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PEPTIDES (2011)
Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history
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TOXICON (2011)
cDNA cloning of conotoxins with framework XII from several Conus species
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The M-superfamily of conotoxins: a review
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INVERTEBRATE NEUROSCIENCE (2010)
Functional Hypervariability and Gene Diversity of Cardioactive Neuropeptides
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Biochemical Characterization of κM-RIIIJ, a Kv1.2 Channel Blocker EVALUATION OF CARDIOPROTECTIVE EFFECTS OF κM-CONOTOXINS
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Evolution of Conus Peptide Genes: Duplication and Positive Selection in the A-Superfamily
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Evolution of Conus peptide toxins: Analysis of Conus californicus Reeve, 1844
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μ-Conotoxins as Leads in the Development of New Analgesics
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Novel conopeptides in a form of disulfide-crosslinked dimer
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PEPTIDES (2010)
Peptide sr11a from Conus spurius is a novel peptide blocker for Kv1 potassium channels
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PEPTIDES (2010)
A new subfamily of conotoxins belonging to the A-superfamily
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PEPTIDES (2010)
Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with γ-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile
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Conopeptide characterization and classifications: An analysis using ConoServer
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ACTA PHARMACOLOGICA SINICA (2009)
Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents
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ARCHIVES OF TOXICOLOGY (2009)
Conantokin-Br from Conus brettinghami and Selectivity Determinants for the NR2D Subunit of the NMDA Receptor
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BIOCHEMISTRY (2009)
Novel αD-Conopeptides and Their Precursors Identified by cDNA Cloning Define the D-Conotoxin Superfamily
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BIOCHEMISTRY (2009)
A Novel Conus Snail Polypeptide Causes Excitotoxicity by Blocking Desensitization of AMPA Receptors
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CURRENT BIOLOGY (2009)
TxXIIIA, an atypical homodimeric conotoxin found in the Conus textile venom
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JOURNAL OF PROTEOMICS (2009)
New conotoxins define the novel I3-superfamily
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PEPTIDES (2009)
Rapid sensitive analysis of cysteine rich peptide venom components
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Cloning and isolation of a conus cysteine-rich protein homologous to Tex31 but without proteolytic activity
Jing Qian et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2008)
Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels NaV1.2, 1.6 and 1.7
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BIOCHEMICAL PHARMACOLOGY (2008)
Three-dimensional structure of conotoxin tx3a: An m-1 branch peptide of the M-superfamily
Owen M. McDougal et al.
BIOCHEMISTRY (2008)
Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus
Yuhong Han et al.
FEBS JOURNAL (2008)
Tyrosine-rich conopeptides affect voltage-gated K+ channels
Julita S. Imperial et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides
Sebastien Dutertre et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Analgesic α-Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation
Brid Callaghan et al.
JOURNAL OF NEUROSCIENCE (2008)
Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus
Duo-Duo Yuan et al.
PEPTIDES (2008)
Two new 4-Cys conotoxins (framework 14) of the vermivorous snail Conus austini from the Gulf of Mexico with activity in the central nervous system of mice
Alejandro Zugasti-Cruz et al.
PEPTIDES (2008)
Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence
Can Peng et al.
PEPTIDES (2008)
Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus
Li Liu et al.
TOXICON (2008)
Characterization of a novel ψ-conotoxin from Conus parius Reeve
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TOXICON (2008)
I1-superfamily conotoxins and prediction of single D-amino acid occurrence
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TOXICON (2008)
Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins
Ping Chen et al.
TOXICON (2008)
Conantokin-P, an unusual conantokin with a long disulfide loop
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TOXICON (2008)
Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels
Junliang Liu et al.
PEPTIDES (2007)
Conolysin-mt:: A Conus peptide that disrupts cellular membranes
Jason S. Biggs et al.
BIOCHEMISTRY (2007)
Structure and sodium channel activity of an excitatory I1-superfamily conotoxin
Olga Buczek et al.
BIOCHEMISTRY (2007)
αC-Conotoxin PrXA:: A new family of nicotinic acetylcholine receptor antagonists
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BIOCHEMISTRY (2007)
A vasopressin/oxytocin-related conopeptide with γ-carboxyglutamate at position 8
Carolina Moeller et al.
BIOCHEMICAL JOURNAL (2007)
Conotoxins of the O-superfamily affecting voltage-gated sodium channels
S. H. Heinemann et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
An assessment of the antinociceptive efficacy of intrathecal and epidural Contulakin-G in rats and dogs
Jeffrey W. Allen et al.
ANESTHESIA AND ANALGESIA (2007)
Solution structure of an M-1 conotoxin with a novel disulfide linkage
Wei-Hong Du et al.
FEBS JOURNAL (2007)
Discovery and characterization of the short kappa A-conotoxins: A novel subfamily of excitatory conotoxins
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TOXICON (2007)
Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus
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GENOMICS (2006)
μO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
J. Ekberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Novel O-superfamily conotoxins identified by cDNA cloning from three vermivorous Conus species
Dongting Zhangsun et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2006)
Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels
V. Sabareesh et al.
PEPTIDES (2006)
Characterization of novel M-superfamily conotoxins with new disulfide linkage
Yu-Hong Han et al.
FEBS JOURNAL (2006)
A single γ-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide
Karin Hansson et al.
BIOCHEMISTRY (2006)
Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern
Can Peng et al.
PEPTIDES (2006)
Identification of a novel class of nicotinic receptor antagonists - Dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum
Marion Loughnan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins
JS Imperial et al.
BIOCHEMISTRY (2006)
Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail
Sebastien Dutertre et al.
FEBS LETTERS (2006)
Synthetic μO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity
G Bulaj et al.
BIOCHEMISTRY (2006)
A novel M-superfamily conotoxin with a unique motif from Conus vexillum
H Jiang et al.
PEPTIDES (2006)
Amino acid sequence and biological activity of a γ-conotoxin-like peptide from the worm-hunting snail Conus austini
A Zugasti-Cruz et al.
PEPTIDES (2006)
A biologically active hydrophobic T-1-conotoxin from the venom of Conus spurius
MB Aguilar et al.
PEPTIDES (2006)
Analysis of expressed sequence tags from the venom ducts of Conus striatus:: focusing on the expression profile of conotoxins
CH Pi et al.
BIOCHIMIE (2006)
Definition and characterization of the short αA-conotoxins:: A single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor
RW Teichert et al.
BIOCHEMISTRY (2006)
A novel conotoxin framework with a helix-loop-helix (Cs α/α) fold
C Möller et al.
BIOCHEMISTRY (2005)
A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues
MB Aguilar et al.
BIOCHEMISTRY (2005)
Postischemic administration of CGX-1051, a peptide from cone snail venom, reduces infarct size in both rat and dog models of myocardial ischemia and reperfusion
NL Lubbers et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2005)
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family - Structural and functional characterization
M Bayrhuber et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Definition of the M-conotoxin superfamily:: Characterization of novel peptides from molluscivorous Conus venoms
GP Corpuz et al.
BIOCHEMISTRY (2005)
αS-conotoxin RVIIIA:: A structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors
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BIOCHEMISTRY (2005)
Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels
G Bulaj et al.
BIOCHEMISTRY (2005)
Polypeptide chains containing D-γ-hydroxyvaline
K Pisarewicz et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor
RW Teichert et al.
JOURNAL OF NEUROSCIENCE (2005)
The A-superfamily of conotoxins - Structural and functional divergence
AD Santos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Three-dimensional structure of the mini-M conotoxin mr3a
OM McDougal et al.
BIOCHEMISTRY (2004)
αA-Conotoxin OIVA defines a new αA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors
RW Teichert et al.
TOXICON (2004)
The metal-free and calcium-bound structures of a γ-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M
MA Grant et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The first γ-carboxyglutamic acid-containing contryphan -: A selective L-type calcium ion channel blocker isolated from the venom of conus marmoreus
K Hansson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
κM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist
A Al-Sabi et al.
BIOCHEMISTRY (2004)
Isolation and characterization of three novel Gla-containing Conus marrmoreus venom peptides, one with a novel cysteine pattern
K Hansson et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Ziconotide: Neuronal calcium channel blocker for treating severe chronic pain
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CURRENT MEDICINAL CHEMISTRY (2004)
Solution structure of the cyclic peptide contryphan-Vn, a Ca2+-dependent K+ channel modulator
T Eliseo et al.
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Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily
TJ Milne et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels
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Characterization and three-dimensional structure determination of ψ-conotoxin PIIIF, a novel noncompetitive antagonist of nicotinic acetylcholine receptors
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Novel excitatory Conus peptides define a new conotoxin superfamily
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A novel conotoxin from Conus betulinus, κ-BtX, unique in cysteine pattern and in function as a specific BK channel modulator
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Contryphan-Vn:: a modulator of Ca2+-dependent K+ channels
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
A novel Conus peptide ligand for K+ channels
M Ferber et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T
AB Malmberg et al.
PAIN (2003)
Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif
LA Miles et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Three-dimensional solution structure of the sodium channel agonist/antagonist δ-conotoxin TxVIA
T Kohno et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency
EC Jimenez et al.
EPILEPSY RESEARCH (2002)
Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin family
M Lirazan et al.
TOXICON (2002)
Conorfamide, a Conus venom peptide belonging to the RFamide family of neuropeptides
M Maillo et al.
TOXICON (2002)
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
JE Chatterton et al.
NATURE (2002)
Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter
IA Sharpe et al.
NATURE NEUROSCIENCE (2001)
Contryphans from Conus textile venom ducts
EC Jimenez et al.
TOXICON (2001)
Mechanisms for evolving hypervariability: The case of conopeptides
SG Conticello et al.
MOLECULAR BIOLOGY AND EVOLUTION (2001)
λ-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding -: Isolation and characterization from the venom of Conus marmoreus
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Structures of the contryphan family of cyclic peptides. Role of electrostatic interactions in cis-trans isomerism
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BIOCHEMISTRY (2000)
Isolation and characterization of a novel Conus peptide with apparent antinociceptive activity
JM McIntosh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors
SD Donevan et al.
MOLECULAR PHARMACOLOGY (2000)
Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa -: 1.: Isolation, characterization and chemical synthesis
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EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
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