期刊
MARINE DRUGS
卷 12, 期 6, 页码 3754-3769出版社
MDPI
DOI: 10.3390/md12063754
关键词
amino alcohols; pseudoaminols; Pseudodistoma sp.; stereochemistry; bioactivities
资金
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Science, ICT and Future Planning) [2010-0020429, 2009-0083533]
- National Research Foundation of Korea [2010-0020429] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Seven new amino alcohol compounds, pseudoaminols A-G (1-7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na+/K+-ATPase.
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