期刊
MARINE DRUGS
卷 12, 期 2, 页码 840-850出版社
MDPI AG
DOI: 10.3390/md12020840
关键词
soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity
资金
- National Science Council [100-2320-B-110-001-MY2]
- NSYSU-KMU JOINT RESEARCH PROJECT [NSYSUKMU 02C030117]
- Aim for the Top University Program from Ministry of Education of Taiwan [02C030205]
New cembranoids, sarcocrassocolides P-R (1-3) and four known compounds (4-7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3-5 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 1-7 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells.
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