期刊
MARINE DRUGS
卷 12, 期 4, 页码 2326-2340出版社
MDPI
DOI: 10.3390/md12042326
关键词
sponge; rare actinomycete; Amycolatopsis; benzofuran; cyclopiazonic acid
资金
- National Research Foundation of Korea (NRF) - Korean government (Ministry of Science, ICT and Future Planning) [M1A5A1-2010-0020429]
Three new secondary metabolites, amycofuran (1), amycocyclopiazonic acid (2), and amycolactam (3), were isolated from the sponge-associated rare actinomycete Amycolatopsis sp. Based on combined spectroscopic analyses, the structures of 1-3 were determined to be a new benzofuran glycoside and new indole alkaloids related to cyclopiazonic acids, a class that has previously only been reported in fungi. The absolute configurations of 1 and 3 were deduced by ECD calculations, whereas that of 2 was determined using the modified Mosher method. Amycolactam (3) displayed significant cytotoxicity against the gastric cancer cell line SNU638 and the colon cancer cell line HCT116.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据