4.7 Review

Microcystin-LR and Cylindrospermopsin Induced Alterations in Chromatin Organization of Plant Cells

期刊

MARINE DRUGS
卷 11, 期 10, 页码 3689-3717

出版社

MDPI
DOI: 10.3390/md11103689

关键词

microcystin; cylindrospermopsin; cyanobacterial toxin; plant chromatin; microtubules

资金

  1. Hungarian National Research Foundation [OTKA K81370, F046493, GVOP-3.2.1.-2004-04-0110/3.0, GVOP-TST 3.3.1-05/1-2005-05-0004/3.0]
  2. [TAMOP-4.2.2/B-10/1-2010-0024]

向作者/读者索取更多资源

Cyanobacteria produce metabolites with diverse bioactivities, structures and pharmacological properties. The effects of microcystins (MCYs), a family of peptide type protein-phosphatase inhibitors and cylindrospermopsin (CYN), an alkaloid type of protein synthesis blocker will be discussed in this review. We are focusing mainly on cyanotoxin-induced changes of chromatin organization and their possible cellular mechanisms. The particularities of plant cells explain the importance of such studies. Preprophase bands (PPBs) are premitotic cytoskeletal structures important in the determination of plant cell division plane. Phragmoplasts are cytoskeletal structures involved in plant cytokinesis. Both cyanotoxins induce the formation of multipolar spindles and disrupted phragmoplasts, leading to abnormal sister chromatid segregation during mitosis. Thus, MCY and CYN are probably inducing alterations of chromosome number. MCY induces programmed cell death: chromatin condensation, nucleus fragmentation, necrosis, alterations of nuclease and protease enzyme activities and patterns. The above effects may be related to elevated reactive oxygen species (ROS) and/or disfunctioning of microtubule associated proteins. Specific effects: MCY-LR induces histone H3 hyperphosphorylation leading to incomplete chromatid segregation and the formation of micronuclei. CYN induces the formation of split or double PPB directly related to protein synthesis inhibition. Cyanotoxins are powerful tools in the study of plant cell organization.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据