期刊
MARINE DRUGS
卷 11, 期 6, 页码 2054-2068出版社
MDPI
DOI: 10.3390/md11062054
关键词
soft coral-derived fungus; Aspergillus elegans; phenylalanine derivative; cytochalasin; antifouling
资金
- National Natural Science Foundation of China [41130858, 41176121]
- National High Technology Research and Development Program of China (863 Program) [2013AA093001]
- Natural Science Foundation of Shandong Province [ZR2011HM085]
- Program for New Century Excellent Talents in University, Ministry of Education of China [NCET-11-0472]
- Natural Science Foundation of Hainan Province [213021]
One new phenylalanine derivative 4'-OMe-asperphenamate (1), along with one known phenylalanine derivative (2) and two new cytochalasins, aspochalasin A1 (3) and cytochalasin Z24 (4), as well as eight known cytochalasin analogues (5-12) were isolated from the fermentation broth of Aspergillus elegans ZJ-2008010, a fungus obtained from a soft coral Sarcophyton sp. collected from the South China Sea. Their structures and the relative configurations were elucidated using comprehensive spectroscopic methods. The absolute configuration of 1 was determined by chemical synthesis and Marfey's method. All isolated metabolites (1-12) were evaluated for their antifouling and antibacterial activities. Cytochalasins 5, 6, 8 and 9 showed strong antifouling activity against the larval settlement of the barnacle Balanus amphitrite, with the EC50 values ranging from 6.2 to 37 mu M. This is the first report of antifouling activity for this class of metabolites. Additionally, 8 exhibited a broad spectrum of antibacterial activity, especially against four pathogenic bacteria Staphylococcus albus, S. aureus, Escherichia coli and Bacillus cereus.
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