New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells

Seven new azalomycin F analogs (1-7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F-5a monoester (1), 23-valine demalonylazalomycin F-5a ester (2), 23-(6-methyl) heptanoic acid demalonylazalomycins F-3a ester (3), F-4a ester (4) and F-5a ester (5), 23-(9-methyl) decanoic acid demalonylazalomycin F-4a ester (6) and 23-(10-methyl) undecanoic acid demalony lazalomycin F-4a ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F-3a, F-4a and F-5a. Biological assays exhibited that 1-7 showed broad-spectrum antimicrobial and anti HCT-116 activities.