期刊
MARINE DRUGS
卷 10, 期 10, 页码 2181-2207出版社
MDPI
DOI: 10.3390/md10102181
关键词
cancer; apoptosis; marine cyanobacteria; natural compounds
资金
- Portuguese Foundation for Science and Technology (FCT) [PTDC/MAR/102638/2008, PTDC/MAR/099642/2008, PTDC/MAR/102258/2008, PesT-C/MAR/LA0015/2011, BTI/PTDC/MAR/102638/2008/2010-025]
- Fundação para a Ciência e a Tecnologia [PTDC/MAR/102638/2008, PTDC/MAR/102258/2008, PTDC/MAR/099642/2008] Funding Source: FCT
Marine cyanobacteria have been considered a rich source of secondary metabolites with potential biotechnological applications, namely in the pharmacological field. Chemically diverse compounds were found to induce cytoxicity, anti-inflammatory and antibacterial activities. The potential of marine cyanobacteria as anticancer agents has however been the most explored and, besides cytotoxicity in tumor cell lines, several compounds have emerged as templates for the development of new anticancer drugs. The mechanisms implicated in the cytotoxicity of marine cyanobacteria compounds in tumor cell lines are still largely overlooked but several studies point to an implication in apoptosis. This association has been related to several apoptotic indicators such as cell cycle arrest, mitochondrial dysfunctions and oxidative damage, alterations in caspase cascade, alterations in specific proteins levels and alterations in the membrane sodium compounds with potential anticancer properties is presented and a review on the implication of apoptosis as the mechanism of cell death is discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据