期刊
MARINE DRUGS
卷 10, 期 10, 页码 2222-2233出版社
MDPI
DOI: 10.3390/md10102222
关键词
Neorhodomela aculeate; red alga; polybromocatechol compounds; antiviral activity; human rhinovirus
资金
- Korea Institute of Science and Technology institutional program [2Z03550]
An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2-6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC50) of 2.50 mu g/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC50 of 7.11 mu g/mL, and anti-HRV3 activity, with an IC50 of 4.69 mu g/mL, without demonstrable cytotoxicity at a concentration of 20 mu g/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.
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