期刊
MARINE DRUGS
卷 10, 期 9, 页码 1993-2001出版社
MDPI AG
DOI: 10.3390/md10091993
关键词
marine endophyte; Scyphiphora hydrophyllacea; meroterpenes; Guignardia sp.; MRSA; Staphylococcus aureus
资金
- National Natural Science Foundation of China [30560018, 20862020]
- National Non-profit Institute Research Grant of ITBB [ITBBZD0841]
Four new meroterpenes, guignardones F-I (1-4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1-6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.
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