期刊
MARINE DRUGS
卷 10, 期 12, 页码 2817-2825出版社
MDPI
DOI: 10.3390/md10122817
关键词
marine alga; Laurencia okamurai; bisabolane sesquiterpene; C-12-acetogenin; brine shrimp lethality
资金
- Natural Science Foundation of China [30530080, 31270403]
- National Marine 863 Project [2007AA09Z403]
- Department of Science and Technology of Shandong Province [2006GG2205023]
In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A-D (1-4), a new chamigrane derivative, okamurene E (5), and a new C-12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C-12-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD50 1.8 mu M.
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