期刊
MARINE DRUGS
卷 10, 期 3, 页码 551-558出版社
MDPI AG
DOI: 10.3390/md10030551
关键词
angucyclinone; epoxybenz[a]anthracene; marine Streptomyces; cytotoxicity
资金
- project of Public science and technology research funds projects of ocean [200905021-3]
Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 mu M. It appears to have potential as an anticancer agent with selective activity.
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