期刊
MARINE DRUGS
卷 10, 期 2, 页码 439-450出版社
MDPI AG
DOI: 10.3390/md10020439
关键词
Sinularia crassa; crassarosterosides A-D; crassarosterol A; anti-inflammatory activity; o-tolylthiocarbamate
资金
- National Science Council of Taiwan [NSC98-2113-M-110-002-MY3]
- Ministry of Education [98C031702]
One new sterol, crassarosterol A (1), and four new steroidal glycosides, crassarosterosides A-D (2-5) were isolated from the Formosan soft coral Sinularia crassa. The absolute configuration of 1 was determined using the Mosher's method. The absolute configurations for the sugar moieties of 2-5 were determined by HPLC analysis on the o-tolylthiocarbamates derived from the liberated sugar after acid hydrolysis. Compounds 2 and 4 could significantly inhibit the expression of pro-inflammatory iNOS protein at 10 mu M. In contrast, 1-3 were found to stimulate the expression of COX-2 protein at this concentration. Steroids 1 and 4 also showed cytotoxicity toward the selected human liver cancer cells.
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