期刊
MARINE DRUGS
卷 10, 期 3, 页码 617-626出版社
MDPI
DOI: 10.3390/md10030617
关键词
soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity
资金
- Ministry of Education [00C030205]
- National Science Council of Taiwan [NSC 98-2113-M-110-002-MY3, 100-2320-B-110-001-MY2]
Three new cembranoids, sarcocrassocolides M-O (1-3), have been isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1-3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell lines and display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.
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