期刊
MARINE DRUGS
卷 10, 期 6, 页码 1192-1202出版社
MDPI
DOI: 10.3390/md10061192
关键词
nonribosomal peptide synthetase; NRPS; marine sponge; Porifera; metagenomics
资金
- Deutsche Forschungsgemeinschaft [SFB630, TP A5]
Genomic mining revealed one major nonribosomal peptide synthetase (NRPS) phylogenetic cluster in 12 marine sponge species, one ascidian, an actinobacterial isolate and seawater. Phylogenetic analysis predicts its taxonomic affiliation to the actinomycetes and hydroxy-phenyl-glycine as a likely substrate. Additionally, a phylogenetically distinct NRPS gene cluster was discovered in the microbial metagenome of the sponge Aplysina aerophoba, which shows highest similarities to NRPS genes that were previously assigned, by ways of single cell genomics, to a Chloroflexi sponge symbiont. Genomic mining studies such as the one presented here for NRPS genes, contribute to on-going efforts to characterize the genomic potential of sponge-associated microbiota for secondary metabolite biosynthesis.
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