期刊
MARINE DRUGS
卷 10, 期 6, 页码 1203-1211出版社
MDPI AG
DOI: 10.3390/md10061203
关键词
soft coral; eunicellin-based diterpenes; cytotoxicity; Klyxum simplex
资金
- Ministry of Education [00C030205]
- National Science Council of Taiwan [NSC 98-2113-M-110-002-MY3, 100-2320-B-110-001-MY2]
Four new eunicellin-based diterpenes, simplexins P-S (1-4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3-5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
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