期刊
MARINE DRUGS
卷 10, 期 5, 页码 1019-1026出版社
MDPI AG
DOI: 10.3390/md10051019
关键词
Briareum excavatum; briarane-type diterpenoid; cytotoxicity; anti-HCMV
资金
- National Science Council [NSC99-2628-B-110-002-MY3]
- Ministry of Education of Taiwan
In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A-C (1-3) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-5 and their cytotoxicity against selected cancer cell lines were evaluated.
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