期刊
MARINE DRUGS
卷 10, 期 2, 页码 427-438出版社
MDPI AG
DOI: 10.3390/md10020427
关键词
menelloide; germacrane; Menella; lobocrassin; cembrane; Lobophytum; elastase
资金
- National Museum of Marine Biology and Aquarium [100100101, 100200311]
- National Dong Hwa University
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University [00C-0302-05]
- Taiwan Department of Health Clinical Trial and Research Center of Excellence [DOH 101-TD-B-111-004]
- National Science Council, Taiwan [NSC 100-2325-B-291-001, 99-2323-B-291-001, 98-2320-B-291-001-MY3]
A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils.
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