期刊
MARINE DRUGS
卷 10, 期 7, 页码 1433-1444出版社
MDPI AG
DOI: 10.3390/md10071433
关键词
Sarcophyton ehrenbergi; cembranoids; cytotoxicity; anti-HCMV
资金
- National Science Council [NSC99-2628-B-110-002-MY3]
- Ministry of Education of Taiwan
In order to search for new bioactive substances from marine organisms, we have investigated the acetone extracts of the soft coral Sarcophyton ehrenbergi collected at San-Hsian-Tai, Taitong County, Taiwan. Chromatographic fractionation of the extracts of the octocoral S. ehrenbergi led to the isolation of three new cembranoids, (+)-12-ethoxycarbonyl-11Z-sarcophine (1), ehrenbergol A and B (2 and 3). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, metabolites 1-3 were evaluated in vitro for their cytotoxicity towards selected cancer cell lines and antiviral activity against human cytomegalovirus (HCMV).
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