期刊
MARINE DRUGS
卷 10, 期 12, 页码 2691-2697出版社
MDPI AG
DOI: 10.3390/md10122691
关键词
dibenzooxepine derivative; 1-hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione; marine-derived fungus; fungal metabolites
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [21603012]
- Grants-in-Aid for Scientific Research [21603012] Funding Source: KAKEN
1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione (1) was obtained from the culture broth of a marine-derived fungus, Beauveria bassiana TPU942, isolated from a marine sponge collected at Iriomote Island in Okinawa, together with two known compounds, chrysazin (2) and globosuxanthone A (3). The structure of 1 was elucidated on the basis of its spectroscopic data (HREIMS, 1D and 2D NMR experiments including H-1-H-1 COSY, HMQC and HMBC spectra). Dibenz[b,e]oxepines are rare in nature, and only six natural products have been reported. Therefore, compound 1 is the seventh natural product in this class. Compounds 2 and 3 showed an antifungal activity against Candida albicans, and 3 inhibited the cell growth against two human cancer cell lines, HCT-15 (colon) and Jurkat (T-cell lymphoma). Compound 1 did not show an apparent activity in the same bioassays.
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